Effect of TDP on microvessel formation of autogenous fat transplantation in mice

Abstract:

Objective：To investigate the effect of TDP on microvessel formation of autogenous fat transplantation in mice. Methods：Totally 72 female mices were divided into TDP group，insulin group and control group randomly and animal model of fat transplanta－tion was established. The region of autogenous fat transplantation was treated with TDP for 30 mins at a time，3 times pre day in TDP group. Autogenous fat transplantation was treated with insulin（concentration of 300 mU/L） in insulin group，the fat transplantation in control group was untreated.The microvessel density in fat transplantation was determined by immunohistochemical method. Results：Microvessel density was higher in TDP group and insulin group than in control group（P<0.05） at 10 d after the operation. Microves－sel density was higher in TDP group compared with that of control group at 20 d and 28 d after the operation. Conclusion：It shows that TDP could improve survival rate of autogenous fat transplantation by promoting vessel formation.