Abstract:【】 Objective To investigate the effect of indwelling catheter thrombolysis on deep venous thrombosis(DVT) of lower extremity and the related nursing process. Methods: 245 cases of mixed deep venous thrombosis, received traditional therapy combined with indwelling catheter thrombolysis were retrospected. Results: In all of the 245 cases, 219 were clinically cured(89.39%), 26(10.61%) were markedly improved, the overall effective rate is 100%. Conclusion: The indwelling catheter thrombolysis is effective for DVT. The perioperation nursing,timely observation,prevention and handling of complications are the guarantees for elevation the therapeutic effect, prevention pulmonary embolism, decreases the sequelaes of disease.