Expression and clinical pathological significance of KAI1 and Smad4 protein in non-small cell lung carcinoma

Abstract:

Objective：To investigate the expressions and correlations of KAI1 and Smad4 protein in non-small cell lung carcinoma （NSCLC） and to study their pathological significance and function in NSCLC. Methods：Totally 150 cases of NSCLC were chosen as experimental group and 60 cases of normal lung tissues as control group. The expressions of KAI1 and Smad4 protein were examined by immunohistochemistry and were analyzed along with their clinical pathological characteristics and prognosis of NSCLC in order to observe the differences in expressions and correlations among them. Results：The expressions of KAI1 and Smad4 were lower in ex－perimental group than in control group（P<0.000 1）. The expressions of KAI1 and Smad4 were correlated with differentiation，lymph node metastasis，pleural invasion and clinical stage（P<0.000 1）. The expressions of KAI1 and Smad4 were correlated with prognosis of NSCLC（P<0.000 1）. Conclusions：The lower expressions of KAI1 and Smad4 can promote the occurrence and development of NSCLC. The combined detection of KAI1 and Smad4 protein postoperatively might be helpful to predict the prognosis of NSCLC.