Prognostic factors of WHO Ⅲ grade glioma patients treated with radiotherapy or chemotherapy

Abstract:

Objective：To study the prognostic factors of WHO Ⅲ grade glioma patients treated with radiotherapy or chemotherapy. Methods：Totally 59 gliomas patients were included in this study. All patients within six weeks after the operation began radiotherapy with total average dose of 59.4 Gy and received chemotherapy at four weeks after radiotherapy. They were divided into radiotherapy （RT） group and combined radiochemotherapy（RCT） group according to their treatment methods after the operation. All patients were followed up periodically after treatment. Survival probabilities were estimated based on Kaplan-Meyer survival analysis and Log rank test. Cox proportional-hazards model was used for multivariate regression analysis. Results：The prolonged overall survival time was affected by age，good physical condition，anaplastic oligodentrocytoma histological diagnosis，complete resection or radiotherapy plus PCV chemotherapy. Based on the median survival time of the terminal node，all patients in this study were divided into four groups. Patients received radiotherapy plus PCV chemotherapy after complete resection without depending on histological diagnosis and those with incomplete resection but the best physical condition（ECOG score was 0 grade） can be expected to achieve a longer lifetime. Based on the postoperative clinical environment，the current results can be used to estimate the probability of survival. Conclusions：The grouping can successfully predict the survival time of patients with WHO Ⅲ grade glioma. Physical condition，extent of resection，his－tological diagnosis and treatment methods are the major determinants for the survival time of patients.