Application of Glutamine in three-dimensional conformal radiotherapy combined with XELOX regimen for patients with advanced gastric cancer

Abstract:

Objective：To evaluate the effect of Glutaimne（Gln） on gastrointestinal tract reactions in patients with advanced gastric can－cer who undergo concurrent chemoradiotherapy. Methods：Totally 47 patients with locally advanced inoperable gastric cancer or local recurrence after radical resection were randomly divided into treatment group and control group. The trentment group were treated with three-dimensional conformal radiotherapy combined with XELOX（Oxaliplatin + Capecitabine） regimen，and oral Gln（tid） at the same time until the end of treatment. The control group only received the same concurrent chemoradiotherapy. Short-term efficacy，life quality and side effects were observed during treatment. Results：Completion rates in treatment group and control group were 87.5% and 60.9%（P=0.03），respectively. Incidences of oral mucositis，nausea/vomiting，abdominal pain/diarrhea and other gastrointestinal re－actions in treatment group were lower than those in control group（P<0.05 ），while life quality was higher in treatment group than in control group（P<0.05）. There was no significant difference（P >0.05） in complete response（CR），partial response（PR） and response rate（RR） between the two groups. Conclusions：Application of Gln in concurrent chemoradiotherapy for patients with gastric cancer can reduce chemotherapy-induced gastrointestinal side effects，improve compliance and life quality of patients.