Effects of obesity on pulmonary inflammation and function

Abstract:

Objective：To detect the effects of obesity on pulmonary inflammation and function in mice. Methods：Male ICR mice were fed with high fat diet for 150 d from the 21st d postnatal after weaning to establish obese mice model（high fat group） while those in control group were given standard chow diets. Mice in high fat group with weight 10%-20% heavier than the normal were classified into overweight group；mice in high fat group with weight 20% heavier than the normal were classified into obesity group. Basic lung function was recorded；pathological HE staining and immunohistochmistry labeling macrophages（F4/80） were performed to measure lung inflammation. Results：（1）Pathological HE staining and immunohistochmistry（F4/80） of pulmonary tissues showed that inflam－matory cell infiltration in alveolar septum and around bronchus was increased in obesity group than in control group and overweight group（especially macrophages）. （2）Pulmonary function（peak inspiratory flow；peak expiratory flow；50% tidal volume expiratory flow） showed no significant difference between these groups. Conclusions：Obesity enhances lung inflammation，however，makes no difference in ventilation function.