Relationship between color Doppler sonography resistance index and cervical carcinoma angiogenesis

Abstract:

Objective：To observe the relationship among resistance index（RI） of transvaginal color Doppler flow imaging（TV-CD－FI），tumor angiogenesis evaluation criterion-microvessel density（MVD） and clinical stage，to evaluate carcinoma angiogenesis from different perspectives and to discuss the value of TV-CDFI in cervical cancer diagnosis and prognosis. Methods：Hospitalized pa－tients from the Maternal and Child Health Hospital of Guiyang were divided into the 2 groups：cervical cancer group（n=30） and con－trol group（n=30）. Patients in cervical cancer group were confirmed by pathology and were subdivided into two groups（n=15） accord－ing to clinical stage Ⅰ and Ⅱ. Patients were examined by TV-CDFI before operation. Morphological features of tumors，arterial blood flow signals within tumors and RI were recorded for later analysis. RI of uterine arteries was measured in control group. Cervical tis－sue slice were made by using excised cervical specimen of patients. Immunohistochemistry Envision method was adopted to detect MVD levels in cervical tissues in cervical cancer group and control group. Results：RI values detected by TV-CDFI were decreased significantly and CD34 marked MVD levels were increased markedly in cervical cancer group compared with those in control group，with statistical differences（P<0.05）. MVD and RI in cervical cancer group showed negative linear correlation（rs=-0.56，P<0.05）. Clini－cal stage Ⅰ and stage Ⅱ in cervical cancer were positively correlated with RI values，P<0.05，but not with MVD levels. Conclusions：Angiogenesis characteristics of cervical cancer can be reflected by RI and MVD，which are negative correlated.With the advantages of higher sensitivity，non-invasive，repetable and preoperation acquisition，RI is more effective in detecting angiogenesis of cervical can－cer than TV-CDFI and has greater values in clinical application.