Effects of candesartan cilexetil on vascular endothelial function in rats with acute myocardial infarction

Abstract:

Objectives：To study the effects of candesartan cilexetil（CAN） on vascular endothelial function in rats with acute myocar－dial infarction. Methods：Rats were randomized into acute myocardial infarction（AMI） group，sham-operation group and CAN group. Rats were sacrificed at two weeks after the intervention and blood pressure（BP），levels of blood nitric oxide（NO） and angiotension Ⅱ（AngⅡ），activities of nitric oxide synthase（NOS），endothelial vasomotor function of isolated thoracic aorta strips were explored. Re－sults：Compared with those in sham-operation group，levels of serum NO and activities of NOS were lower，function of endothelium-dependent diastoles（EDDs） was decreased seriously while levels of plasma AngⅡ were distinctly higher in AMI group，with significant statistical differences（P=0.000 4）. After CAN treatment，levels of serum NO and activities of NOS were obviously higher，almost reaching the similar levels in sham-operation group；meanwhile function of EDDs in isolated aortic strips was improved greatly（P=0.000 9） and levels of plasma AngⅡ were increased significantly，however，BP in all groups was not affected. Conclusions：CAN can greatly improve the disordered endothelial function of rats with acute myocardial infarction without affecting BP.