Preliminary study on the role of serum soluble intercellular adhesion molecule-1 in the pathogenesis of hepatitis B virus related liver diseases

Abstract:

Objective：To explore the role of serum intercellular adhesion molecule-1（sICAM-1） in the pathogenesis of hepatitis B virus related liver diseases by detecting the levels of sICAM-1 in patients with hepatitis B virus related liver diseases. Methods：Lev－els of sICAM-1 were measured by enzyme-linked immunosorbent assay（ELISA） in the 120 subjects（30 patients with chronic hep－atitis B，30 patients with liver cirrhosis，30 patients with liver failure and 30 health controls）. Results：Serum levels of sICAM-1 were higher in patients with chronic hepatitis B，cirrhosis and liver failure than in healthy controls（P=0.029，P=0.000 07，P=0.000 1）. In patients with hepatitis B virus related liver diseases，sICAM-1 levels were positively correlated with levels of alanine aminotransferase（ALT），aspartate aminotransferase（AST），total bilirubin（TBIL）（ALT：rs=0.240，P=0.023；AST:rs=0.225，P=0.033；TBIL：rs=0.262，P=0.013）and were negatively correlated with the levels of albumin（ALB），prothrombin activity（PTA）（ALB：rs=-0.297，P=0.005；PTA：rs=-0.218，P=0.039）. Conclusions：sICAM-1 may interfere the procedure of immunological damage of hepatitis B and plays an impor－tant role in the pathogenesis of live fibrosis and cirrhosis. Examination of serum levels of sICAM-1 in patients with hepatitis B virus related liver diseases can be used to judge the patients’ condition.