Effects of rasagiline on monoamine oxidase in mouse liver and brain tissues

Abstract:

Objective：To investigate the inhibition of rasagiline on monoamine oxidase（MAO） in mouse liver and brain tissues. Methods：After being extracted by differential centrifugation，activities of MAO-A and MAO-B in mouse liver and brain tissues were determined by UV spectrophotometry respectively. Results：Inhibition effect of rasagiline was stronger on MAO-B than on MAO-A and inhibition effect of rasagiline was stronger in the brain than in the liver. Conclusion：Rasagiline exerts selective inhibition effects on MAO-B in mouse liver and brain tissues.