Synthesis of monoamine oxidase inhibitor intermediate 1，2，3，4-tetrahydro-1-naphthylamine hydrochloride

Abstract:

Objective：To design a method for synthesizing 1，2，3，4-tetrahydro-1-naphthalenamine hydrochloride，which is an impor－tant intermediate for monoamine oxidase（MAO） inhibitors. Methods：1，2，3，4-tetrahydro-1-naphthylamine hydrochloride（11） was synthesized from benzene via acylation，reduction，cyclization，condensation，reduction，and salification by methods of Fridel Crafts acylation，Ｗolf-kishner-HUANG Minglong reduction and Harwoth cyclization. Results：Overall yield for synthesizing 1，2，3，4-te－trahydro-1-naphthylamine hydrochloride（11） was 43.6%. Conclusions：Method for synthesizing 1，2，3，4-tetrahydro-1-naphthale－namine hydrochloride is establish. Optimized synthetic route has advantages in industrial production for its cheap and readily available raw materials，easy in operation，high yield and high quality of products.