Correlation between apolipoprotein E gene promoter polymorphisms and cerebral vasospasm after spontaneous subarachnoid hemorrhage

Abstract:

Objective：To investigate the correlation between apolipoprotein E gene（APOE） promoter polymorphisms and cerebral vasospasm（CVS） after spontaneous subarachnoid hemorrhage（SAH）. Methods：One hundred and one patients with spontaneous SAH were selected in this study. Venous blood samples and clinical data of patients were collected. APOE promoter polymorphisms of all patients were determined by polymerase chain reaction-restriction fragment length polymorphism. Degrees of CVS after SAH were de－termined by transcranial Doppler. APOE promoter polymorphisms and clinical data of CVS after SAH were analyzed by χ2 test and Logistic regression. Results：In all patients，incidence of CVS in -219T group was significantly higher than that in -219G group（P=0.024）. Univariate and multivariate Logistic regression analyses also showed that promoter -219T was a risk factor of CVS incidence. Conclusion：-219T alleles in APOE promoter region is the risk factor of CVS after spontaneous SAH.