Effects of heparin sodium on the prethrombotic state in lung cancer patients with peripherally inserted central catheter

Abstract:

Objective：To study the effect of heparin sodium（125 U/ml） for locking on the prethrombotic state in lung cancer patients with peripherally inserted central catheter（PICC）. Methods：Clinical data of 20 lung cancer patients with PICC were randomly select－ed in our department. Heparin sodium（125 U/ml） was used for locking after PICC being inserted. All parameters in our study includ－ing prothromhin time（PT），activated partial thromboplsatin time（APTT），thrombin time（TT），fibrinoge（Fbg），platelet（PLT） and D-dimer were dynamically monitored 2 times：0~1 d before（T0） and 2~3 d after（T1）PICC insertion. Results：Differences in PLT and D-dimer between T0 and T1 were significant（t=2.387，P=0.028；t=2.487，P=0.022）. There was no significant difference in PT，APTT，TT，Fbg，FDP between T1 and T0. Conclusions：①Using heparin sodium（125 U/ml） for locking is safe for patients with lung cancer after PICC insertion. ②Heparin sodium（125 U/ml） for locking can reduce PLT and D-dimer levels of patients with lung cancer after PICC insertion and can prevent venous thrombosis.