Expressions and significances of chemokines MIP-1α，MIP-1β and MCP-1 in autoimmune thyroid disease

Abstract:

Objective：To explore the role and development of chemokines macrophage inflammatory protein-1α（MIP-1α），macro-phage inflammatory protein-1β（MIP-1β） and monocyte chemoattractant protein-1（MCP-1） in adults with autoimmune thyroiditis. Methods：Totally 44 cases of Graves disease（GD），19 cases of hashimoto thyroiditis（HT），14 cases of thyroid adenoma，10 cases of multinodular goiter and 8 cases of surrounding normal tissues were collected. Expressions of chemokines MIP-1α，MIP-1β and MCP-1 were determined by immunehistochemical method. Results：Chemokines MIP-1α，MIP-1β and MCP-1 were located in the cytoplasm of the thyroid follicular epithelial cells. Expression levels and scores of chemokines MIP-1α，MIP-1β and MCP-1 were significantly higher in GD and HT than in multinodular goiter and thyroid normal tissues. Conclusions：Chemokines MIP-1α，MIP-1β and MCP-1 may participate in the development of the autoimmune thyroid diseases and may become new targets of monitoring and treatment of autoimmune thyroid diseases.