Expressions and significances of FAK，FAKpY397 and Src in hepatocellular carcinoma

Abstract:

Objective：To detect the expressions of focal adhesion kinase（FAK），phospho-focal adhesion kinase Y397（FAKpY397） and sceroid recptor coactivator（Src） in heaptocellular carcinoma（HCC） and the relationship among them. Methods：Expressions of FAK，FAKpY397 and Src in 8 cases of normal tissues and 44 cases of HCC tissues were detected by immunohistochemical techniques and manual counting. Results：Expressions of FAK，FAKpY397 and Src were higher in HCC tissues than in normal tissues（P=0.027，P=0.041，P=0.030） and had relationship with the differentiation of HCC（P=0.026，P=0.045，P=0.005）. Expressions of FAK and Src were higher in low differentiated HCC than in high differentiated HCC（P=0.015，P=0.002）. Positive relationship was found between expres－sions of FAK，FAKpY397 and Src in HCC tissues（P=0.000，P=0.000，P=0.000）. Conclusions：Expressions of FAK，FAKpY397 and Src in HCC tissues have relationship with the differentiation of HCC. Expressions of FAK and Src are higher in low differentiated HCC than in high differentiated HCC and correlation is existed between them.