Expressions of fibulin-5 and their relationship with angiogenesis in epithelial ovarian tumor

Abstract:

Objective：To investigate expressions of fibulin-5 and their relationship with angiogenesis in epithelial ovarian tumor. Methods：Blood flow signals of ovarian tumor were detected preoperatively by color Doppler ultrasound and resistance index（RI） was used for analysis. Expressions of fibulin-5 and CD34 in 89 patients with epithelial ovarian tumor were assessed by immunohistochemi－cal SP method after operation. Microvessel density（MVD） was counted with endothelial cells marked by CD34.Relationship between expressions of fibulin-5 and tumor biological behavior was analyzed by MVD combined with clinical pathological parameters. Correla－tion among fibulin-5，MVD and RI in epithelial ovarian carcinoma was analyzed． Results：There were significant differences in positive expression of fibulin-5 among benign，border and malignant epithelial ovarian tumors（ ?字2=20.654，P=0.000）. MVD among benign，bor－der and malignant tumors showed ascendant trend and there were significant differences between groups（F=88.97，P=0.000）. Median of RI was significantly lower in ovarian carcinoma than in benign epithelial ovarian tumor（ ?字2=12.200，P=0.002） and it was negatively correlated with MVD（rs=-0.676，P=0.000）. There were statistical significances in positive expressions of fibulin-5 among different clinical stages in ovarian carcinoma，but there was no difference among different age，differentiation degrees and pathological types. Positive expressions of fibulin-5 in ovarian carcinomas were negatively correlated with MVD（rs=-0.650，P=0.000） and were positively correlated with RI（rs=0.430，P=0.004）. Conclusions：Expression of fibulin-5 protein is reduced with the progression of epithelial ovari－an tumor and it is correlated with the tumor angiogenesis.