Correlation between morning blood pressure surge and renal damage at early stage and observation on antihypertensive effects

Abstract:

Objective：To research effect of morning blood pressure surge（MBPS） on renal damage at early stage and antihypertensive treatment. Methods：By 24-hour ambulatory blood pressure monitoring（ABPM），hypertensive patients were divided into MBPS group（n=121） and non-MBPS group（n=131）. All patients underwent urine microalbumin（mALB） quantitative determination. At 6 months after treatment，all patients underwent ABPM and mALB again. Effect of MBPS on renal damage at early stage and changes of renal function after the disappearance of MBPS were studied. Results：Before treatment，average systolic pressure at 24 h and at day and night of patients with MBPS was significantly higher than that in non-MBPS group，with statistical differences. After treatment，blood pressure of both groups reached the standard and had no significant difference；MBPS was disappeared in MBPS group. Before treat－ment，mALB of patients with MBPS was significantly higher than that in non-MBPS group（72.0±13.6） mg/L vs. （43.0±14.6） mg/L，with statistical differences，P＜0.05. After treatment，mALB of both groups was decreased，more obviously in MBPS group，P＜0.05. There were statistical differences in mALB of MBPS group and non-MBPS group before and after the treatment，P＜0.05 and P<0.01. Conclusions：MBPS aggravates renal function damage and eliminating MBPS will help protect renal function.