Hepatic pathological and clinical relationship in early cirrhosis patients infected with different HBV genotypes

Abstract:

Objective：To discuss differences in HBV genotypes and nontraumatic indexes commonly used in clinics between chron－ic hepatitis B（CHB） patients with early cirrhosis and CHB patients without cirrhosis. Methods：Totally 178 patients with CHB were selected randomly for liver biopsy pathological examination and underwent hierarchical diagnosis. All patients were divided into non cirrhosis group（S0-S3 stage） and early cirrhosis group（S4 stage）. Real-time fluorescence quantitative polymerase chain reaction（PCR） was used to do HBV genotype. Results：There were 134 cases in non cirrhosis group，accounting for 75.3%；44 cases in cirrhosis group，accounting for 24.7%. There were differences in gender，age and HBeAg expression between two groups. Proportion of C geno－type was much higher in cirrhosis group（55.6%） than in non cirrhosis group（22.2%），with statistical differences. There was no statis－tical difference in numerical change of HBV DNA between cirrhosis group and non cirrhosis group. There were statistical differences in total bilirubin，alkaline phosphatase，gamma-glutamyltranspeptidase，aspertate aminotransferase，albumin，globulin，prealbumin，cholinesterase，platelet，spleen intercostal thickness between two groups. Conclusions：Among all clinically diagnosed CHB patients，24.7% have early cirrhosis based on the results of liver biopsy，indicating 1/4 patients’ condition may be underestimated. Pathological changes of liver tissue are significantly heavier in CHB patients with C genotype than those with B genotype. B，C genotype classifi－cation combined with liver biopsy helps to determine the severity and prognosis of disease，conducive to the treatment and assessment.