Expressions of KAI1/CD82 in colorectal carcinoma and their relationship with clinicopathological characteristics

Abstract:

Objective：To investigate expressions of KAI1/CD82 in colorectal carcinoma and their correlation with the metastasis of col－orectal carcinoma. Methods：Tissue microarray and immunohistochemistry were used to detect expressions of KAI1/CD82 in 233 cases of colorectal carcinoma. Results：Positive rate of KAI1/CD82 expression in colorectal carcinoma was 51.5%. Expressions of KAI1/CD82 were not correlated with patients’ sex，age，depth of infiltration and lymphnode metastasis，but were correlated with differentia－tion degrees and Dukes stages（P<0.05）. Forward stepwise binary Logistic regression revealed that differentiation was the most signifi－cant influencing factor of KAI1/CD82 expression，Exp（b）=0.431，P=0.038，followed by Dukes stage，Exp（b）=0.363，P=0.043. Expres－sions of KAI1/CD82 were decreased in colorectal carcinoma with poor differentiation and at Dukes D stage. Conclusions：Expressions of KAI1/CD82 are closely correlated with differentiation degrees and stages，which are expected to become a new target for tumor prognosis.