Association of polymorphism of Fetuin-A gene rs2248690 with polycystic ovary syndrome in Chongqing Han population

Abstract:

Objective：To investigate the association of Fetuin-A gene rs2248690 single nucleotide polymorphisms（SNPs） with poly－cystic ovary syndrome（PCOS） in Chongqing Han population. Methods：A total of 147 PCOS patients and 156 controls were genotyped by TaqMan SNP genotyping assay. Hyperinsulinemic-euglycemic clamp was performed on 147 PCOS women and 20 controls. M value was used to signify insulin sensitivity. Results：No significant difference in genotype and allele frequencies of rs2248690 was observed between PCOS patients and controls（OR=4.432，P=0.09，95%CI=0.925 to 21.224；OR=1.123，P=0.57，95%CI=0.751 to 1.679；respectively）. Patients with AA genotype had higher fasting serum insulin，homeostasis model assessment-insulin resistance and lower M value as compared with those of AT and TT genotypes in PCOS group（P=0.00，P=0.00）. Conclusions：Fetuin-A gene rs2248690 poly－morphism has no association with PCOS in Han population in Chongqing area，but it may associate with insulin resistance in PCOS.