Effects of trace element Strontium on serum indexes of rats with type 1 diabetes mellitus

Abstract:

Objective：To investigate the effects of mineral water containing different concentration of Strontium（Sr） on contents of blood glucose，glycosylated hemoglobin（ＧHb），serum triglycerides（TG），free fatty acid（FFA） and total cholesterol（TC） in rats with type 1 diabetes mellitus（T1DM）. Methods：Totally 150 adult Wistar rats weighing 220~250 g，half male and half female were used in the experiment. One-time intraperitoneal injection of streptozotocin（60 mg/kg） was administrated to rats. Three days later，rats with fasting blood glucose more than 16.7 mmol/L were taken as DM model rats.Then DM rats were randomly divided into group A（drinking mineral water with Sr 2 mg/L），group B（drinking mineral water with Sr 4 mg/L），group C（drinking mineral water with Sr 6 mg/L），group D（rats drinking mineral water with Sr 8 mg/L） and DM group（drinking tap water）. Rats were sacrificed randomly at 1，2，3，4 months later and the indexes mentioned above were detected and compared. Results：There was no significant difference in the overall condition between groups A，B，C，D groups and DM group at the first four months（all P >0.05）. At the first month，blood glucose was decreased in groups B and C than in DM group（P<0.05）；at the second，third and fourth month，there was no statistical difference in blood glucose between groups A，B，C，D and DM group. At the first and second month，FFA was obviously decreased in groups A，B，C，D than in DM group（P<0.05）；at the third and fourth month，FFA was obviously decreased in group D than in DM group（P<0.05）. At the first month，TG was obviously decreased in groups B，C，D（most obviously in group D） than in DM group（P<0.01）；at the second month，TG was obviously decreased in group D than in DM group（P<0.05）；at the third and fourth month，there was no differ－ence in TG between groups A，B，C，D and DM group（P >0.05）. At the first month，There was no significant difference in TC between groups A，B，C，D and DM group（P >0.05）；at the second month，TC was decreased in group D than in DM group（P<0.05）；at the third and fourth month，there was no difference in TC between groups A，B，C，D and DM group（P >0.05）. Conclusions：Race ele－ment strontium exerts no obvious effects on reducing glucose and GHb，but has significant effect on reducing FFA，TG and TC in rats with T1DM.