Insulin resistance of patients with chronic hepatitis induced diabetes mellitus and its clinical significance

Abstract:

Objective：To investigate islet β cell function and insulin resistance（IR） in the patients with hepatogenous diabetes（HD）. Methods：Oral glucose tolerance test and insulin releasing test were carried out on 37 patients with hepatogenous diabetes（HD） and 58 patients with type 2 diabetes（T2DM）. Plasma glucose and insulin levels at 0，30，120，180 min were measured. Homeostasis mod－el assessment islet beta cell function（HOMA-β），early phase indexes of insulin secretion（EISI） and late phase indexes of insulin secretion（LISI） were used to evaluate islet beta cell function. Homeostasis model assessment-insulin resistance（HOMA-IR） and hepatic insulin resistance index（HIR） were used to assess IR. Results：Fasting plasma glucose level in HD group was lower than that in T2DM group，but 2-hour postprandial plasma glucose，insulin level at each time point，HOMA-IR，HIR，HOMA-β and LISI in HD group were significantly higher than those in T2DM group（P<0.05）. There was no significant difference in age，sex，disease course and glycosylated hemoglobin Alc and EISI between HD and T2DM groups（P>0.05）. Conclusions：Patients with HD may present high postprandial plasma glucose，early phase insulin secretion damage and hyperinsulinemia with IR.