Improvement of reproductive function of patients with ectopic pregnancy after treatment of methotrexate combined with mifepristone

Abstract:

Objective：To investigate the effects of methotrexate（MTX） combined with mifepristone and rhubarb mirabilite on reproduc－tive function after ectopic pregnancy. Methods：Totally 202 patients with unruptured tubal pregnancy，stable vital signs，blood human chorionic gonadotropin（HCG） under 2 000 IU/ L，age under 35 years，integrity clinical data and requirements for fertility were enrolled. They were divided into two groups according to their wishes；95 patients in study group chose conservative medical treatment and 107 patients in control group chose laparoscopic surgery and reserved fallopian tubes. Reproductive status and occurrence of complications were followed up for 1.5 to 4.0 years after the treatment. Results：Rates of pregnancy and infertility were 37.9% and 62.1% in study group and 37.4% and 62.6% in control group. Rates of live birth in study group and control group were 61.1% and 62.5% respec－tively，without statistically significant differences（P >0.05）. Rate of recurrent ectopic pregnancy in study group（5.3%） was significant－ly lower than that in control group（22.4%），with statistically significant differences（P<0.01）. Conclusions：Conservative medical treat－ment can achieve similar reproductive outcome as laparoscopic surgery and can reduce incidences of recurrent ectopic pregnancy.Therefore，conservative medical treatment is a safe，effective and inexpensive method and can achieve satisfactory long-term repro－ductive status.