Value of ureteroscopic lithotripsy combined with ntrap in treatment of upper urethral calculi：a Meta analysis

Abstract:

Objective：To systematically review the effectiveness and safety of ureteroscopic lithotripsy combined with ntrap for upper urethral calculi. Methods：All randomized clinical trials and case-controlled studies of ntrap during ureteroscopic lithotripsy（URL） for upper urethral calculi were identified with PubMed，Cochrane Librily，Embase，WangFang and CNKI. Quality assessments of litera－tures and data extraction were independently performed by two reviewers. Meta analysis was performed with Revman 5.0. Results：Two randomized trails and 2 case-controlled studies involving 682 patients were collected. Meta-analysis demonstrated that：ntrap group demonstrated a significant advantage over control group in terms of calculi clearance rate（OR=4.28，95%CI=2.51 to 7.28，P=0.000）. Incidences of calculi migration and auxiliary lithotripsy were significantly lower in ntrap group than in control group（OR=0.09，95%CI=0.01 to 0.62，P=0.01；OR=0.18，95%CI=0.05 to 0.67，P=0.010）. There was no statistical difference in mean operation time between the two groups（WMD=-0.09，95%CI=-10.25 to 10.06，P=0.990）. Conclusions：URL combined with ntrap for upper urethral calculi had higher calculi clearance rate，lower incidence of calculi migration and auxiliary lithotripsy than URL without ntrap.