Expressions and significances of CKS1 and CyclinD1 in breast carcinoma

Abstract:

Objective：To investigate the expressions and significances of cyclin kinase subunit1（CKS1） and CyclinD1 in breast car－cinoma. Methods：Expressions of CKS1 and CyclinD1 in 105 cases of breast carcinoma were assessed by immunohistochemical technique（SP method） and those in 100 cases of breast fibroadenoma（control group） were simultaneously detected. Expressions and significances of CKS1 and CyclinD1 in breast carcinoma tissues were analyzed. Results：Positive rates of CKS1 and CyclinD1 in breast carcinoma were 80.9%（85/105） and 85.7%（90/105）. Positive rates of CKS1 and CyclinD1 in breast fibroadenoma were 22%（22/100） and 19%（19/100）. Positive expressions of two genes were in correlation with lymphatic vessel invasion and lymph node metas－tasis in breast carcinoma. Positive rates of CKS1 and CyclinD1 in breast carcinoma were higher than those in breast fibroadenoma（P<0.05）. Positive expressions of CKS1 and CyclinD1 in breast carcinoma were in positive correlation（r=0.677，P<0.05）. Conclusions：Positive expressions of CKS1 and CyclinD1 are significantly higher in breast carcinoma than in breast fibroadenoma. Positive expres－sions of CKS1 and CyclinD1 in breast carcinoma are positively related with lymphatic vessel invasion and metastasis of lymph node. Expressions of CKS1 and CyclinD1 may play a role in evaluating the prognosis and guiding the clinical treatment for breast carcinoma.