Relationship between coronary heart disease risk and serum angiotensinⅡconcentration in male patients with nonalcoholic fatty liver disease

Abstract:

Objective：To investigate the relationship between coronary heart disease（CHD） risk and serum angiotensinⅡ（AngⅡ） con－centration in male patients with nonalcoholic fatty liver disease（NAFLD）. Methods：All participants were non-smoking males，includ－ing 35 normal controls and 85 NAFLD patients. Fasting serum Ang Ⅱ concentration was measured，insulin resistance（IR） was esti－mated by homeostasis model assessment of insulin resistance（HOMA-IR） and 10-year CHD risk was assessed by Framingham risk score（FRS）. According to the international diabetes federation criteria for metabolic syndrome（MS），NAFLD patients were subdivided into MS（+） and MS（-） groups. According to FRS，NAFLD patients were divided into FRS<0 and FRS≥0 groups. Results：Serum AngⅡ concentration was significantly higher in MS（-） and FRS≥0 groups than in control group（P<0.001） and FRS<0 group（P=0.017），respectively. There was no significant difference in Ang Ⅱ concentration between MS（+） and MS（-） groups. FRS was sig－nificantly higher in MS（-） than in control group（P=0.035），significantly higher in MS（+） group than in MS（-） group（P=0.042）. Ten-year CHD incidence risk ratio was positively associated with fasting plasma insulin，HOMA-IR and serum AngⅡ concentration （r’=0.248，0.335，0.222，P’=0.009，<0.001，0.02）. Conclusions：Increased 10-year CHD risk in male NAFLD patients is positively associated with IR and serum AngⅡ concentration. Inhibition of AngⅡ may decrease CHD risk in male NAFLD patients.