Evaluation on hepatic fibrosis by joint non-invasive method

Abstract:

Objective：To establish a joint non-invasive clinical method and system to assess and evaluate the severity of hepatic fibro－sis of patiants with non-alcoholic fatty liver disease（NAFLD）. Methods：Totally 104 patients with non-alcoholic fatty hepatic fibrosis were divided according to different histopathological stages.Hepatic fibrosis relation indexes，tissue inhibitors of matrix metallopro－teinase-1（TIMP-1），hepatic B ultrasond and liver diffusion weighted imaging（DWI）were detected. Results：There were consider－able correlations between hepatic ultrasond and liver fibrosis grading，with a correlation coefficient of 0.56. Joint non-invasive method combing DWI，liver fibrosis markers and TIMP-1 corrected 84.69% of all trials. Conclusions：This joint non-invasive assessment method is practical and repeatable and is recommended to be a clinical method for diagnosing liver fibrosis.