Effects of rhBMP-2-coated Kirschner wire on the recovery of long tubal bone fracture

Abstract:

Objective：To observe the effects of rhBMP-2-coated Kirschner wire on the recovery of long tubal bone fracture. Methods：Totally 36 new southwest big white rabbits were randomly divided into two groups. Kirschner wire coated with rhBMP-2/poly-D，L-lactide（PDLLA） was inserted into the medullary cavity of fractured tibia in experimental group while Kirschner wire coated with only PDLLA was inserted into the medullary cavity in control group. Bone morphology and bending strength were analyzed and measured at 4，8，12 weeks postoperatively. Results：Osteogenesis was better in experimental group compared with that in control group；fracture stress and maximum stress were higher in experimental group compared with those in control group（P<0.05）. Conclusions：Kirschn－er wire coated with rhBMP-2 and PDLLA can promote the bone fracture recovery and shorten the fracture recovery time with the dis－solution of PDLLA and release of rhBMP-2.