Long term prognostic value of estrogen receptor and progesterone receptor in young patients with breast carcinoma

Abstract:

Objective：To investigate the effects of estrogen receptor（ER） and progesterone receptor（PR） on long term prognosis of young patients with breast cancinoma. Methods：ER and PR statuses in 370 patients with breast cancinoma（younger than 35 year） were immunohistochemical examined and followed up. Results：Totally 366 out of 370 patients were followed up for 24 to 288 months，with an average of 132.64 months. ER and PR positive rates were 44.86%（166/370）and 38.11%（141/370）respectively. ER and PR statuses were not associated with 2-year survival rate and 5-year survival rate. There were differences in 8-，10-，15-year survival rate between ER（+） and ER（-）（ χ2=5.992，P=0.014； χ2=7.025，P=0.008； χ2=6.221，P=0.013）. Eight-year survival rate in PR（+） was higher than that in PR（-）（ χ2=9.552，P=0.002）；2-year survival rate in ER（+）PR（+） was not different from that in ER（-）PR（-）（ χ2=1.963，P=0.161）；but 5-year and 8-year survival rates in ER（+）PR（+） were higher than those in ER（-）PR（-）（ χ2=7.365，P=0.007； χ2=5.236，P=0.022）. Conclusions：ER and PR are important long term prognostic factors in young patients with breast canci－noma. Simultaneous exam of ER and PR is of higher prognostic value. ER（-）PR（-） and ER（-）PR（-） indicate poor prognosis，therefore auxiliary treatment including chemotherapy should actively be put in force and followe up should be strengthen in order to improve the prognosis.