Expression and the clinical significance of MGMT and MMP-7 in human astrocytoma

Abstract:

Objective：To investigate the expression and significance of methylguanine-DNA methyltransferase（MGMT）and matrix metalloproteinase-7（MMP-7） protein in human astrocytoma. Methods：Protein expression of MGMT and MMP-7 was detected in 49 cases of human astrocytoma with SP immunohistochemical method. Results：Expression rate of MGMT was 55.10%（27/49） and those of MMP-7 was 51.02 %（25/49）. Expression of MGMT and MMP-7 protein was related with histological grade（P<0.05），but not re－lated with other clinical factors（P >0.05）. There was significant differences in the MGMT and MMP-7 expression rate between group with recurrence and group without recurrence（P<0.05）. There were significant negative correlations between MGMT and MMP-7 protein expression（rs=-0.488，P<0.01）. Conclusions：MGMT and MMP-7 play important roles in occurrence and development of human astrocytoma. Low expression of MGMT and over expression of MMP-7 provide important implications of malignancy and prognosis for human astrocytoma.