Predictive value of Cox-2 and Salusin-a in the risk stratification of acute coronary syndrome

Abstract:

Objective：To explore the inflammatory factor of Cox-2 and lipid factor of Salusin-a’ s predictive value in the risk stratification of acute coronary syndrome（ACS） and the correlation among it’s main risk factors. Methods：One hundred and ten patients underwent coronary angiography（CAG） were divided into three groups：ACS group（n=61），stable angina pectoris（SAP） group（n=19） and control group（n=30） who had negative results in CAG according to their medical histories and CAG results. ACS group（n=61） was subdivided into acute myocardial infarction（AMI） group and unstable angina pectoris（UAP） group. ACS group was also divided into different groups based on the Gensini scoring system.Plasma levels of Cox-2 and Salusin-a were measured by ELISA. Results：Plasma levels of Cox-2 and high sensitivity-C reactive protein（hs-CRP） were significantly higher in ACS group than in SAP group and control group（（16.39±3.64） ng/ml vs. （13.79±1.76） ng/ml and （13.38±1.98） ng/ml，P=0.001，P=0.000；（（5.61±6.77） mg/L vs. （1.50±1.48） and （1.35±1.49） mg/L，P=0.003，P=0.000）. Plasma levels of Cox-2 and hs-CRP were significantly higher in AMI group than in UAP group （（18.88±3.97） ng/ml vs. （15.09±2.70） ng/ml，P=0.028；（9.05±7.92） mg/L vs. （3.67±5.18） mg/L，P=0.002）. Though Salusin-a level was lower in ACS group and SAP group than in control group（（0.13±0.07） ng/ml and （0.11±0.04） ng/ml vs. （0.18±0.08） ng/ml，P=0.003，P=0.001），it was not significantly different between ACS group and SAP group. Conclusions：Inflammatory factor of Cox-2 and hs-CRP have predictive value in the risk stratification of ACS. Lipid factor of Salisin-a is associated with coronary heart disease，but could not necessarily reflect the severity of the disease.