Effects of curcumin on the expression of SR-BⅠ and ABCA1 in neurons of hippocampus of APPswe/PSEN1dE9 double transgenic mice

Abstract:

Objective：To observe the effect of curcumin on expression of scavenger receptor class B typeⅠ（SR-BⅠ） and ATP-bind－ing cassette transporter 1（ABCA1） in neurons of hippocampus of APPswe/PSEN1dE9 double transgenic mice and to investigate the mechanism of curcumin in the prevention and treatment of Alzheimer’s disease. Methods：Ten six-month-old APPswe/PSEN1dE9 double transgenic mice were randomly divided into control group and curcumin group． Each group had 5 mice. Mice in curcumin group were fed curcumin 500 ppm every day. Six months later，changes of the expression of SR-BⅠ and ABCA1 in neurons of hippicampus were detected by immunohistochemistry. Results：Expression of ABCA1 in neurons of hippocampus of mice in curcumin group was increased significantly compared with that of control group（t=-10.805，P=0.000） while expression of SR-BⅠ was not detected in both groups. Conclusions：Curcumin can induce expression of ABCA1 in neurons of hippocampus of APPswe/PSEN1dE9 double transgenic mice while expressions of SR-BⅠ can not be detected in neurons.