Effects of curcumin on serum total cholesterol and high-density lipoprotein contents and expression of ABCA1 and apoA1 in CA1 region of hippocampus in APP/PS1 double transgenic mice

Abstract:

Objective：To investigate the effect of curcumin on serum total cholesterol（TC） and high-density lipoprotein（HDL） and expression of ATP binding cassette transport protein A1（ABCA1） and apolipoprotein A1（apoA1） in CA1 region of hippocampus in APP/PS1 double transgenic mice. Methods：Alzheimer’s disease（AD） model was established with APP/PS1 double transgenic mice，which were fed for 6 months with different concentrations of curcumin diet. Immunohistochemistry（SP） was applied to evaluate the expressive change of ABCA1 and apoA1 in CA1 region of hippocampus of transgenic mice. Colorimetric method was applied to detect the content of TC and HDL in blood serum of transgenic mice. Results：After feeding transgenic mice with curcumin diet，expression of ABCA1 and apoA1 in CA1 region of hippocampus was increased in concentration dependent manner（P=0.005，0.003；P=0.025，0.001）. Content of HDL in blood serum was increased too while TC was decreased with significant differences between groups（P=0.041，0.010；P=0.046，0.002）. Conclusions：ABCA1 may play an important role in the generation or development of AD. Curcumin may lower the content of cholesterol by raising expression of ABCA1 and content of apoA1 and HDL.