Meta analysis on the relationship between 5-hydroxytryptamine 2A receptor gene polymorphism T102C and depression

Abstract:

Objective：To assess the association of 5-hydroxytryptamine（5-HT）2A receptor gene polymorphism with depression by Meta analysis. Methods：Literatures on the relationship between 5-HT2A receptor gene polymorphism T102C and depression in CBMdisc and PubMed from January 2000 to December 2012 were taken as research objects. Software of RevMan 5.0 was employed to do Meta analysis. Results：Nine literatures were included，enrolling 1 717 for depression and 2 037 for healthy controls. The results showed that there was no significant association between 5-HT2A receptor gene polymorphism and depression including the allele contrast model，homozygote model and heterozygotes genotypes. Conclusions：There is no significant association between 5-HT2A receptor gene polymorphism and depression，5-HT2A receptor single nucleotide polymorphism T102C may not confer the risk of depression as an independent risk factor.