Advance of colorectal cancer’ molecular diagnostic biomarkers-circulating free miRs

Abstract:

MicroRNAs（miRs） are noncoding small RNAs，being single strand in the mature form，which negatively regulate gene expression at the translational level. Recent studies have showed that circulating free miRs will probably play an important role in diagnosing colorectal cancer（CRC）. CRC patients have a specific expression profile of circulating free miRs，among which miR-18a，miR-21，miR-29a，and miR-92a have a potential di－agnostic value for CRC respectively. Moreover，miR-7 may distinguish patients of CRC at early stage from healthy individuals. These significant findings suggest that circulating free miRs are potential molecular diagnostic biomarkers of CRC.