Relationship between JNK signal pathway and cell apoptosis

Abstract:

Molecular mechanism of tumor resistance is very complex including abnormality of chromosome and gene expression，decrease of intracellular drug accumulation，enhancement of DNA damage and repair function，increase of cell detoxification function，disturbance of apoptosis signal-transduction and abnormality of apoptosis inhibitor. Among them，apoptosis and survival related cell signal pathways are the hotspots now. p38 mitogen-activated protein kinase（MAPK） signal pathway is one of the hotspots. One of the important MAPK signal pathways is JNK signal pathway. This review summarized the relationship between JNK and cell apoptosis as well as the function of JNK in tumor resistance.