A Meta analysis on the correlation between TNF-β gene +252 A/Gpolymorphism and susceptibility of gastric cancer

Abstract:

Objective：To explore the relationship between tumor necrosis factor-β（TNF-β）gene +252 A/G polymorphism and suscep－tibility of gastric cancer. Methods：Case-control studies about TNF-β gene +252 A/G polymorphism and susceptibility of gastric cancer were searched from PubMed，Ovid，Springer，CBM，CNKI and Wan fang databases between establishment of databases and June 2013. According to the self-designed inclusion and exclusion criteria，data were extracted and quality of included studies was evaluated. Meta analysis was conducted by using Review Manager 5.2 and Stata 12.0 software with stability being evaluated by both stratified analysis and sensitivity analysis. Moreover，Begg’s funnel plot and Egger’s regression were used to assess the published bias of articles. Results：Sixteen case-control studies were included including 2 538 cases and 3 908 controls. Meta analysis showed that in each genetic model，no significant difference was found in the correlation between TNF-β gene +252 A/G polymorphism and gastric cancer：codominant genetic model（G/G vs. A/A）：OR and 95%CI：0.95（0.76，1.20）；dominant genetic model（（A/G+G/G） vs. A/A）：OR and 95%CI：1.09（0.91，1.32）；recessive genetic model（G/G vs. （A/G+A/A））：OR and 95%CI：0.88（0.72，1.07）；allele genetic model（G vs. A）：OR and 95%CI：1.00（0.90，1.11）.（G/G，G/A，A/A respectively represent the genotype）. There was no statis－tical significance in racial subgroup analysis. Conclusions：TNF-β +252 A/G polymorphism is not significantly related with gastric cancer. The conclusion is limited by the quality and number of included studies. Large-scale studies are needed in the further.