Expression and significance of HO-1 and HO-2 in medulloblastoma

Abstract:

Objective：To investigate the expression and clinical values of heme oxygenase（HO）-1 and HO-2 in medulloblastoma. Methods：Expression of HO-1 and HO-2 in 41 cases of medulloblastoma and 23 cases of control brain tissues was determined by im－munohistochemical assay with SP staining. Relationship between HO-1 and HO-2 expression as well as relationship between HO-1 and HO-2 expression and clinical features（sex，age，histopathology and tumor location） were analyzed with corresponding statistical meth－ods. Results：Expression rates of HO-1 and HO-2 in 41 cases of medulloblastoma were 78.0%（32/41） and 73.2%（30/41） respective－ly，significantly higher than those in control brain tissue（P=0.002，0.001）. Expression of HO-1 was positively related with expression of HO-2（rs=0.477，P=0.009）. There was no difference in gender，age and tumor location between negative and positive of HO-1 and HO-2 groups（HO-1：?字2=0.118，0.000，2.903；P=0.732，1.000，0.424；HO-2：?字2=2.737，1.191，1.169，P=0.098，0.662，0.945）. However，expression of HO-1 and HO-2 showed significant difference in medulloblastoma with different histopathology types（HO-1： ?字2=12.570，P=0.002；HO-2：?字2=6.677，P=0.044）. Conclusions：High expression of HO-1 and HO-2 play an important role in medulloblastoma growth. Futhermore，expression of HO-1 and HO-2 is significantly associated with histopathology of medulloblastoma，indicating that HO-1 and HO-2 may be used as new marker for patient’s state，prognosis and therapeutic target.