Recent advances in the function of aquaporin-4 in central nervous system

Abstract:

Aquaporin-4（AQP-4） is the most abundant aquaporin in central nervous system（CNS）. Water movement cross cell mem－brane is mainly conducted by AQP-4. Previous studies of AQP-4 mainly focused on edema formation after various brain injuries，but recently AQP-4 has been found to connect with many other brain functions and diseases，such as regeneration and inflammation. Therefore，these researches were reviewed to renew current views on AQP-4 in CNS，hoping to provide new threads for the exploration of drugs against AQP-4.