Effects of perindopril on bFGF-2 expression in isoproterenol-induced myocardial hypertrophy of rats

Abstract:

Objective：To explore the effect of perindopril on basic fibroblast growth factor（bFGF-2） expression in isoproterenol（ISO）-induced cardiac hypertrophy of rats. Methods：The research rats were randomly divided into three groups and 10 rats in each group：control group，model group（3mg/（kg·d） isoproterenol for 10 d） and intervention group（3 mg/（kg·d） isoproterenol and 1 mg/（kg·d） perindopril for 10 d）. Left ventricular mass/body mass（LVM/BM） and heart mass/body mass（HM/BM） were detected and compared；in addition，FGF-2 mRNA and protein in left ventricular tissues were analyzed by RT-PCR and immunohistochemistry. Results：Results of LVM/BM and HM/BM in the 3 groups were：control group