Construction of rabbit abdominal hernia model and its criteria

Abstract:

Objective：To explore the feasibility of establishing a stable animal model of abdominal hernia and the criteria to determine its success through animal studies. Methods：The 40 male rabbits were randomly divided into A，B，C and D groups with 10 rabbits in each group. A group was taken as control group and the remaining three groups were taken as experimental groups. Full structure of abdominal wall（muscle and peritoneum）of rabbits in experimental group was cut by sizes of 2 cm×2 cm，3 cm×3 cm，4 cm×4 cm，respectively. Protruding abdominal mass，body weight and mortality of rabbits were observed one month later. Results：There was no significant difference in body weight in groups A，B，C before and after the surgery（P=0.504，0.465，0.090）. Body weight was decreased in group D after the surgery compared with that before the surgery（P=0.000）. No case of abdominal mass and no death case in group A，two cases of abdominal mass and one death case in group B，six cases of abdominal mass and one death case in group C，six cases of abdominal mass and three death cases in group D were observed. Conclusion：Removal of abdominal tissues by size of 3 cm×3 cm can build a stable animal model of abdominal hernia and propose a method to build hernia model and criteria，paving the way for the research of the hernia in the future.