Association of polymorphisms of glucokinase regulatory protein gene with polycystic ovarian syndrome in Chongqing Han population

Abstract:

Objective：To explore the correlation of the glucokinase regulatory protein（GCKR） gene rs3817588 and rs780094 single nucleotide polymorphisms（SNPs） with polycystic ovary syndrome（PCOS） and its related metabolic indices in Chongqing Han popu－lation. Methods：Totally 147 patients with PCOS and 156 normal controls were recruited and genotyped by TaqMan SNP genotyp－ing assay；Hyperinsulinemic-euglycemic clamp was performed on all patients and 20 controls. Results：Nither statistical differences in genotype and allele frequencies of rs3817588（OR=0.929，95%CI=0.541 to 1.594， ?字2=0.72，P=0.79；OR=0.995，95%CI=0.759 to 1.304，?字2=0.00，P=0.97，respectively），nor statistical differences，in genotype and allele frequencies of rs780094（OR=1.427，95%CI=0.974 to 1.598， ?字2=2.74，P=0.10；OR=0.880，95%CI=0.700 to 1.107， ?字2=1.20，P=0.27，respectively） was found between the two groups. Conclusion：GCKR gene rs3817588 and rs780094 polymorphisms have no association with PCOS or its related metabolic factors in Han population in Chongqing.