Clinical characteristics and prognostic factors for prostate cancer in different age groups

Abstract:

Objective：To explore the different clinicopathological characteristics and prognostic factors for patients with prostate cancer （PCa） in different age groups. Methods：All 105 patients diagnosed with PCa from January 2006 to May 2013 were divided into young group（＜60 years，45 patients） and old group（≥60 years，60 patients）. Clinical symptoms，international prostate symptom rating scale （IPSS），total prostate specific antigen（TPSA），clinical staging，Gleason score，incidence of bone metastasis，and treatment in both groups were explored. Results：Frequent micturition and dysuria were the primary symptoms in both groups; there were significant differences in the symptom of ostalgia between the two groups（Z=-2.436，P=0.015）. There were significant differences in the IPSS score，TPSA value，and Gleason score between the two groups（Z=-3.460，P=0.001）（Z=-2.830，P=0.005）（Z=-2.580，P=0.01）. There was no sig－nificant difference in clinical staging（Z=2.500，P=0.114） but there were statistical differences in bone metastasis incidence between the two groups（?字2=4.618，P=0.032）. Fifteen and 26 patients respective in young group and old group received radical prostatectomy；the others underwent endocrine therapy. Conclusion：Frequent micturition and dysuria are the primary symptoms in both groups；but more patients in young group suffer from ostalgia symptom. The symptoms are lighter in young group；but TPSA value，pathological malignant degree and bone metastasis are more severe in young group. There is no difference in clinical staging between the two groups.