Cohort retention in HIV pre-exposure prophylaxis clinical trial among men who have sex with men

Abstract:

Objective：To explore cohort retention and associated factors in HIV pre-exposure prophylaxis（PrEP） clinical trial among men who have sex with men（MSM）. Methods：Totally 297 MSM were enrolled by non-probability sampling methods and then as－signed to daily dose，intermittent dose and blank control arms randomly. Clinical follow-up and questionnaire were carried out every 3 months. Cumulative cohort retention rates of different arms were described by Kaplan-Meier estimation. Univariate and multivariate Cox regression were used to analyze associated factors of cohort retention. Results：43.1%（128/297） of participants completed the fol－low-up in this study and the mean retention time was （5.85±3.99） months. Those who were in intermittent dose arm（AHR=0.62，95%CI＝0.42 to 0.91） and older than 30 years（AHR=0.65，95%CI＝0.47 to 0.90） showed higher cohort retention. Conclusion：The co－hort retention of PrEP clinical trial among MSM in this study is not high. Effective measures should be taken to improve the cohort re－tention of MSM in blank control arm and younger age.