Research progress of iASPP in tumor

Abstract:

The function of wild type p53 is usually inhibited in patients with tumor. The latest research showed that the function of wild type p53 was controlled by apoptosis-stimulating protein of p53（ASPP） family. ASPP family includes three members： iASPP，ASPP1 and ASPP2. Many studies showed that iASPP can inhibit the activity and function of p53；and its expression and function was correlated with clinical characteristics，curative effect and prognosis. It plays important roles in tumor development. In this review，we expect to explore the function and character of iASPP thus to provide a new way for the treatment of tumor using iASPP as target.