Association between HLA-DRB1 alleles polymorphism and hepatocellular carcinoma：a systematic review

Abstract:

Objective：To investigate the correlation between HLA-DRB1*07/12/15 and hepatocellular carcinoma（HCC）. Methods：Articles were identified by electronic search in PubMed，EMBASE，Wanfang data，CNKI. Case-control study trials focusing on the correlation of the risk of HLA-DRB1*07/12/15 with HCC were included. Effective data were extracted from the eligible studies. All Meta analysis were performed by RevMan 5.0 software. ORs were used as effect indicators. Results：HLA-DRB1*12/15 increased the risk of HCC in the whole populations[（OR=1.56，95%CI=1.12 to 2.17，P=0.009）/（OR=1.35，95%CI=1.03 to 1.77，P=0.03）] while HLA-DRB1*07 didn’t correlated with the risk of HCC in the whole populations（OR=0.99，95%CI=0.46 to 2.14，P=0.97）. Subgroup analyzis suggested that：HLA-DRB1*12/15 increased the risk of HCC in Asian populations[（OR=1.65，95%CI=1.17 to 2.32，P=0.004）/（OR=1.55，95%CI=1.14 to 2.11，P=0.006）]，while HLA-DRB1*07 didn’t correlated with the risk of HCC in Asian populations significantly（OR=0.95，95%CI=0.26 to 3.50，P=0.94）. Conclusion：HLA-DRB1*12/15 increases the risk of HCC while HLA-DRB1*07 doesn’t correlate with the risk of HCC.