Changes in serum chemerin level in pregnant women with severe pre-eclampsia and eclampsia

Abstract:

Objective：To discuss the serum chemerin level in pregnant women with severe pre-eclampsia and eclampsia and to ex－plore their relationship． Methods：Fifty patients with severe pre-eclampsia and 2 with eclampsia in Second Affiliated Hospital of Chongqing Medical University from 2011 to 2012 were enrolled. There were 32 cases of early onset pre-eclampsia and 18 cases of late onset pre-eclampsia including 12 cases of fetal growth restriction（FGR）． Thirty normal pregnant women during the same period were taken as control group. Serum chemerin level was determined by ELISA in each group． Results：Serum chemerin level of severe pre-eclampsia and eclampsia group（422.30±60.72） ng/L was higher than that in normal group（316.2±47.87） ng/L（P=0.000）． Serum chemerin level of early onset group（420.94±69.71） ng/L did not differ from that in late onset group（424.89±40.22） ng/L（P=0.812）. Serum chemerin level of FGR sub group（482.17±52.93） ng/L was higher than that in non-FGR sub group（404.35±50.97） ng/L（P=0.000）． Correlation analysis showed that serum chemerin level significantly and positively correlated with systolic blood pressure，diastolic blood pressure，blood urea nitrogen，creatinine，triglycerides and low density lipoprotein（r=0.698，0.654，0.277，0.235，0.288，0.475；P=0.000，0.000，0.012，0.034，0.009，0.000），and negative correlated with high density lipoprotein（r=-0.396，P=0.000）. There was no correlation between serum chemerin level and cholesterol（r=0.178，P=0.110）. Conclusion：The elevated serum chemerin level may contribute to the pathogenesis of severe pre-eclampsia，eclampsia and FGR，and may influence the fetal growth．