Comparison of cyclosporine A dose after living related liver transplantation and donation after cardiac death liver transplantation for children

Abstract:

Objective：To summarize the usage of cyclosporine A in living related liver transplantation（LRLT） and donation after car－diac death（DCD） liver transplantation for children in our hospital and to provide references for standard dose for children after liver transplantation. Methods：Clinical data of 20 cases of LRLT and DCD liver transplantation during June 2006 to May 2013 in our hos－pital were summarized. These 20 recipients were treated by cyclosporine A-based regimen. Differences in CsA dosage after LRLT and DCD liver transplantation were analyzed. Results：In LRLT group，doses at each time period were：（7-18） mg/（kg·d） at initial peri－od，（7-17.5） mg/（kg·d） at one month after the operation，（7-17.5） mg/（kg·d） at two months after the operation；（5-16） mg/（kg·d） at three months after the operation，（4-13.5） mg/（kg·d） at six months after the operation. In DCD group：（16-20） mg/（kg·d） at initial period，（16-19） mg/（kg·d） at one month after the operation，（13.5-15.5） mg/（kg·d） at two months after the operation，（12.5-15） mg/（kg·d） at three months after the operation，（9-13.5） mg/（kg·d） at six months after the operation. There were statistically signifi－cant difference in the dosage of Cs A between LRLT and DCD liver transplantation（P<0.05）. Conclusion：LRLT recipients require less amount of Cs A than DCD recipients during the first six months after receiving liver transplantation with the same drug concen－trations. Large individual difference between the two groups can be observed.