Changes in expression of Th17 cells and related cytokines in multiple sclerosis and its clinical significance

Abstract:

Objective：To investigate the expression of change of Th17 cells and related cytokines in multiple sclerosis patients and its clinical significance. Methods：Totally 27 multiple sclerosis patients（MS group） and 20 healthy subjects（control group） were selected. RT-PCR was used to detect IL-17 mRNA；ELISA was used to detect IL-17，IL-23 and IL-6；FACS was used to detect Th17 cells in peripheral blood. Results：Level of IL-17 mRNA was significantly increased in MS group（P<0.05）. When compared with that control group，expression of Th17 cells and related cytokines（IL-17，IL-23 and IL-6） was significantly increased in MS group（P<0.05）. Conclusion：Th17 cells and related cytokines may participate in the pathogenesis of multiple sclerosis. Detection of Th17 cells could have clinical value in diagnosis of multiple sclerosis.