Clinical observation on efficacy of nasal spray hormone and leukotriene receptor antagonist in the treatment of adenoidal hypertrophy in children

Abstract:

Objective：To investigate the efficacy of nasal spray hormone and leukotriene receptor antagonist in the treatment of ade－noidal hypertrophy in children. Methods：From June 2011 to August 2013，160 adenoidal hypertrophy children were randomly divided to treatment group and control group. The treatment group was subdivided into nasal spray hormone group，leukotriene receptor antag－onist group and combined treatment group. The changes in clinical symptom score and Adenoido/Nasopharyngeal（A/N） ratio were measured. Results：Clinical symptom score was decreased in nasal spray hormone group compared with that in control group，with sta－tistical differences（P=0.000）；A/N ratio in nasal spray hormone group was reduced to lower than 0.60. Clinical symptom score was de－creased in leukotriene receptor antagonist group compared with that in control group，with statistical differences（P=0.000）；A/N ratio in nasal spray hormone group was reduced to lower than 0.71. Clinical symptom score was decreased in combined treatment group compared with that in control group，with statistical differences（P=0.000）；A/N ratio in nasal spray hormone group was reduced to lower than 0.60. Clinical symptom score and efficacy was better in combined treatment group than in nasal spray hormone group and leukotriene receptor antagonist group（P=0.05，P=0.001，P=0.001）. Conclusion：Both nasal spray hormone（Rhinocort） and leukotriene receptor antagonist（Montelukast） are effective in improving symptoms in children with adenoid hypertrophy. The clinical efficacy of combined treatment is better than that of single-drug treatment.